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Transcriptomic Analysis Highlights Brain Gene Expression Differences in ADHD

Gene expression differences affecting neurotransmitter activity in the brains of people with attention deficit hyperactivity disorder (ADHD) versus individuals without the condition are reported in Molecular Psychiatry this week. While recent research has uncovered many rare and common genetic variants that confer risk for ADHD, these studies have relied on imputation from genotype to predict gene expression in different brain regions, limiting their utility. In the newly published study, a team led by National Human Genome Research Institute researchers performed RNA sequencing on post-mortem brain tissue from 60 ADHD patients and matched controls, focusing on two regions of the brain — the caudate nucleus and anterior cingulate cortex — that are implicated in the disorder. They uncover significant downregulation of neurotransmitter gene pathways in the ADHD samples, as well as transcriptomic changes that are also found in other neurodevelopmental and mood disorders. "This transcriptomic evidence points to cortico-striatal neurotransmitter anomalies in the pathogenesis of ADHD, consistent with current models of the disorder," the study's authors write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.