Skip to main content
Premium Trial:

Request an Annual Quote

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to the development of motor neuron disease among individuals already genetically predisposed to the condition, Sky News reports. It adds that the researchers behind the new study note that most people who take part in vigorous exercise do not develop motor neuron disease.

The University of Sheffield's Pamela Shaw and her colleagues used a Mendelian randomization approach to test whether exercise contributed to MND or amyotrophic lateral sclerosis risk as well as a transcriptomic analysis to explore whether ALS-linked genes were expressed during exercise based on UK Biobank data. As they report in eBioMedicine, the researchers found that many of the genes known to increase ALS risk change their expression in response to strenuous exercise and that people with the most common ALS-linked gene variant tend to develop the disease earlier if they take part in vigorous exercise regularly.

"This research goes some way towards unraveling the link between high levels of physical activity and the development of MND in certain genetically at-risk groups," Shaw tells BBC News.

Co-author Johnathan Cooper-Knock, also of Sheffield, adds at Sky News that he "wouldn't advise anybody to change their exercise habits because we don't know who is at risk at the moment."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.