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Team Tallies Preclinical Lab Study Reporting Impediments, Improvement Opportunities

In PLOS Biology, researchers at Ottawa Hospital, the Ottawa Hospital Research Institute, and the University of Ottawa outline factors that impact preclinical laboratory study reporting and related study designs. Through interviews with 30 preclinical scientists, the team explored potential reporting barriers and factors that may enhance reporting — from awareness of such guidelines and available resources, time, personnel, education, and training to investigators' desire for reliable, high-quality study design — in an effort to bolster preclinical research design and reporting strategies in the future. "Using existing guidance … we mapped and coded our interview findings to identify potential interventions, policies, and implementation strategies to improve routine use of the guidelines by preclinical scientists," they write. "These findings will help inform specific strategies that may guide the development of programs and resources to improve experimental design and transparent reporting in preclinical research."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.