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Team Tallies Domain Features From Human Protein Structure Predictions

University of Texas Southwestern Medical Center researchers report in a paper that is to appear in the Proceedings of the National Academy of Sciences on findings from a computational analysis focused on human proteome structure predictions corresponding to specific protein domains. "Identifying domains in these predicted structures and classifying them into an evolutionary hierarchy can reveal biological insights," they reason. Using manual curation and automated pipeline, the team tracked down some 47,576 globular domains, for example, evaluating evolutionary relationships between them, as well as their similarities to experimentally defined domains. The globular domain set includes stretches of sequence spanning more than 2,500 disease-associated SNPs, the authors note, along with domains that seem to have been expanded or contracted in humans compared to other animals. "[C]omparison with automatically classified domains from multiple model organisms revealed differences associated with the unique physiology of humans, such as expansion in cytokines and depletion of odor-sensing domains," they report.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.