Skip to main content
Premium Trial:

Request an Annual Quote

Team Presents Benchmark Study of RNA Classification Tools

Investigators at India's National Agri-Food Biotechnology Institute consider computational strategies for classifying protein coding- and non-coding RNA, using the top tools to put together an RNAChallenge validation test set containing well-supported transcripts. For the analysis, the team used data from 135 transcriptomic datasets to test 24 tools and dozens of computational models for distinguishing coding and non-coding transcripts, ultimately using insights from 48 models contributing to 17 of the computational tools to put together a validation set dubbed RNAChallenge. "This [RNAChallenge] validation set is also helpful in detecting false positives and false negatives, a problem commonly found in the biological domain," the authors explain, noting that their broader analysis of existing computational models pointed to "significant room for improving the tools by addressing these issues."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.