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Tailored Colorectal Cancer Drug Combinations Proposed with Modeling, Organoid Approach

In Journal of Experimental and Clinical Cancer Research, researchers from the University of Geneva and elsewhere present a personalized cancer treatment strategy that relies on ex vivo organoid testing and mathematical modeling to focus in on optimized drug combinations — an approach they applied to primary and metastatic colorectal cancer (CRC) cases. Starting with a "Therapeutically Guided Multidrug Optimization" (TGMO) phenotypic method, the team tracked down a handful of optimized drug combinations (ODCs) with apparent activity in three-dimensional CRC models, subsequently testing the ODCs in patient-derived organoids from primary or metastatic CRC cases that were further assessed by exome and RNA sequencing. "Optimizing low-dose synergistic drug combinations is an attractive strategy to tackle the complex machinery of cancer and to overcome, or more importantly, to prevent acquired drug resistance," they write. "The simultaneous targeting of key signaling pathways at different levels or targeting distinct signaling pathways is essential to efficiently kill cancer cells.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.