Skip to main content
Premium Trial:

Request an Annual Quote

Survivors of Childhood Cancer Show Faster Epigenetic Aging

Faster epigenetic aging among adolescent cancer survivors is associated with increased risk of early-onset obesity, as well as increased morbidity, a new study in JAMA Network Open reports. Previous work had suggested that epigenetic age acceleration was higher among childhood cancer survivors than others who had not had cancer, and in the new study, a St. Jude Children's Research Hospital-led team harnessed an expansion of the St Jude Lifetime Cohort dataset to include more DNA methylation data to explore changes in epigenetic aging. Within this cohort of nearly 3,000 patients, the researchers found children and adolescents who were cancer survivors had higher annual changes in epigenetic aging. The researchers further noted that this increased epigenic aging rate was linked to an increased risk of developing obesity before the age of 20 — a common health condition among young cancer survivors — as well as other chronic health conditions. "Their young chronologic age at presentation highlights the importance of potential early entry point for antiaging interventions including nonpharmacologic (eg, lifestyle modifications) and pharmacologic (eg, DNA methylation or demethylating agents) strategies to reduce morbidity and mortality during survivorship care," the researchers write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.