Skip to main content
Premium Trial:

Request an Annual Quote

Study Uncovers Potential New Drug Targets for Liver Fibrosis

Using RNA sequencing and other technologies, a team led by scientists from Icahn School of Medicine at Mount Sinai has identified several potential new therapeutic targets for liver fibrosis. The prevalence of non-alcoholic fatty liver disease is rapidly increasing globally, with a large number of patients progressing to a more advanced stage of the disease — called nonalcoholic steatohepatitis (NASH) and for which there are no approved therapies — involving the activation of hepatic stellate cells (HSCs) to drive hepatic fibrosis. The researchers used single-nucleus RNA-seq and advanced 3D imaging to profile gene expression changes in in HSCs from both human and murine NASH, uncovering a profibrotic autocrine signaling loop comprising dozens of receptor-ligand pairs that emerges in hepatic stellate cells specifically during late-stage disease. As reported in Science Translational Medicine this week, they show that inhibiting one of these receptor-ligand interactions pharmacologically could reduce advanced fibrosis in a mouse model of NASH. "The findings suggest a therapeutic paradigm in which stage-specific therapies could yield enhanced antifibrotic efficacy in patients with advanced hepatic fibrosis," the study's authors write

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.