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Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

In Lancet Regional Health – Americas, members of the Zika Brazilian Cohorts Consortium present findings from a meta-analysis focused on offspring from pregnant women infected with the Zika virus (ZIKV) during an epidemic in Brazil from 2015 to 2017. Using data for 1,548 women with RT-PCR-verified ZIKV infections, the team saw miscarriage in 0.9 percent of pregnancies and stillbirth in another 0.3 percent of pregnancies. For infants born live, meanwhile, the researchers identified microcephaly in 4 percent of offspring. Still other children born to ZIKV-infected mothers had neurological, auditory, ophthalmic, and other abnormalities, they report, though just 1 percent had multiple abnormalities. "Our findings suggest that approximately one-third of the children born to ZIKV-positive pregnant women present with at least one abnormality compatible with congenital infection," the authors report, noting that "congenital abnormalities are more likely to present in isolation than in combination."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.