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Study Reveals How Antibody Cocktail Neutralizes Lassa Virus

New details about how an investigational antibody cocktail offers protection against Lassa virus infection are reported in Science Translational Medicine this week, providing a therapeutic strategy for combating the pathogen. The virus causes hemorrhagic Lassa fever, a serious and often fatal condition that affects hundreds of thousands of people, primarily in West Africa, each year. In previous studies, scientists from the La Jolla Institute for Immunology and collaborators identified three neutralizing antibodies — obtained from patients who had survived multiple Lassa virus infections — that target the Lassa virus glycoprotein complex, which the virus uses to enter host cells. When tested in non-human primates, the antibody combo provided complete protection against the virus. Seeking to better understand how these antibodies work, the researchers conducted a series of experiments that reveal the mechanisms by which the antibodies neutralize Lassa virus and offer guidelines for designing treatments for Lassa fever and related infectious diseases.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.