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Study Links Genetic Risk for ADHD With Alzheimer's Disease

Genetic risk for attention-deficit/hyperactivity disorder (ADHD) is associated with age-related cognitive deterioration and the development of signs of Alzheimer's disease later in life, according to a study appearing this week in Molecular Psychiatry. Aiming to investigate a proposed link between ADHD and neurodegenerative conditions such as Alzheimer's disease, a team led by scientists from the US and Brazil calculated an ADHD polygenic risk score (PRS) for 212 cognitively unimpaired older adults. Importantly, a range of data were available for the individuals including MRI brain scans, baseline amyloid-beta and tau levels measured on PET scans and in cerebrospinal fluid, and six years of cognitive assessments. The researchers show that a high AHDH PRS was associated with greater cognitive decline and the development of Alzheimer's disease brain pathophysiology over six years. The link between ADHD and Alzheimer's disease, the study's authors add, was mostly observed in amyloid-beta-positive individuals, suggesting that the genetic liability for ADHD increases susceptibility to the harmful effects of amyloid-beta pathology

The Scan

Study Links Evolution of Longevity, Social Organization in Mammals

With the help of comparative phylogenetics and transcriptomics, researchers in Nature Communications see ties between lifespan and social organization in mammals.

Tumor Microenvironment Immune Score Provides Immunotherapy Response, Prognostic Insights

Using multiple in situ analyses and RNA sequence data, researchers in eBioMedicine have developed a score associated with immunotherapy response or survival.

CRISPR-Based Method for Finding Cancer-Associated Exosomal MicroRNAs in Blood

A team from China presents in ACS Sensors a liposome-mediated membrane fusion strategy for detecting miRNAs carried in exosomes in the blood with a CRISPR-mediated reporter system.

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.