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Study Explores Expression Features Distinguishing Prostate Cancer, Chronic Pancreatitis

Chinese researchers reporting in BMC Genomics look at long non-coding RNA (lncRNA) and messenger RNA patterns that coincide with chronic pancreatitis progression to pancreatic cancer. Using array-based expression data from a public database, coupled with PCR-based testing, the team profiled mRNAs and lncRNAs in 103 pancreatic samples from dozens of individuals with chronic pancreatitis or pancreatic ductal adenocarcinoma (PDAC), searching for lncRNAs and mRNAs that are differentially expressed. They further characterized the differentially expressed RNAs with network analyses and protein-protein interaction clues, which highlighted two expression modules. "These findings provided novel insights into the molecular mechanism and potential diagnostic or therapeutic biomarkers for [chronic pancreatitis] and PDAC," the authors report. "Future studies could explore the differential diagnostic value of lncRNAs and validate the roles of downstream mRNAs in cancer therapy."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.