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Study Explores Causal Ties Between Pregnancy Outcomes, Genetic Risk of Insomnia

For a paper in PLOS Medicine, a team led by investigators at the University of Bristol, the Norwegian Institute of Public Health, and other centers used Mendelian randomization to analyze pregnancy and perinatal outcomes such as hypertension, gestational diabetes, stillbirth, preterm birth, or birthweight in relation to dozens of insomnia-associated SNPs in nearly 356,100 women with European ancestry from several large population studies. The analyses pointed to "some evidence in support of a possible causal relationship between genetically predicted insomnia and miscarriage, perinatal depression, and [low birth weight]," the authors report, noting that the broader results "highlight the importance of healthy sleep in women of reproductive age, though replication in larger studies, including with genetic instruments specific to insomnia in pregnancy, are important."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.