Skip to main content
Premium Trial:

Request an Annual Quote

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

For a paper appearing in Genome Biology, a Technical University of Munich-led team evaluates a suite of sequence-based transcription regulation models, setting in silico results against assay data for a range of tissue and developmental stages and results from CRISPR-based enhancer knockdown experiments and several other perturbation assays. While available models often unearthed authentic regulatory variants falling in promoter regions, the investigators saw poorer performance by these sequence-based models when it came to gauging the gene expression effects of mid- to long-range enhancer elements. "Our results suggest that sequence-based models have advanced to the point that in silico study of promoter regions and promoter variants can provide meaningful insights and we provide practical guidance on how to use them," the authors suggest. "Moreover, we foresee that it will require significantly more and particularly new kinds of data to train models accurately accounting for distal elements."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.