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From STRs to Next-Gen Sequencing

DNA forensics relies on analysis of short tandem repeats, but the Atlantic writes that newer tools and technologies are also being adapted to aid law enforcement investigations.

For instance, it notes that a break in a 25-year-old murder investigation came recently when investigators turned to DNA phenotyping by the Virginia-based Parabon NanoLabs that used a DNA sample left at the crime scene to put together a picture of what the suspect might look like.

Next-generation sequencing is also beginning to enter the field, the Atlantic says. It notes that the Illumina spin-out Verogen is now offering a forensics kit that works on Illumina sequencers to provide not only STR data, but also analyzes ancestry and traits like hair and eye color. But as Verogen's Cydne Holt tells the Atlantic, forensics scientists are a conservative lot. DNA sequencers are still undergoing validation for use in crime labs, it notes.

Despite that, the Atlantic notes that there's little oversight of how law enforcement uses DNA forensics. The New York Times and ProPublica recently critiqued of some of the algorithms used in STR analysis by the New York medical examiner.

"There will be new ways of using DNA to solve crimes, but there may be new ways of misusing DNA, too," the Atlantic cautions.

The Scan

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.

Study Presents New Insights Into How Cancer Cells Overcome Telomere Shortening

Researchers report in Nucleic Acids Research that ATRX-deficient cancer cells have increased activity of the alternative lengthening of telomeres pathway.

Researchers Link Telomere Length With Alzheimer's Disease

Within UK Biobank participants, longer leukocyte telomere length is associated with a reduced risk of dementia, according to a new study in PLOS One.

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.