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From STRs to Next-Gen Sequencing

DNA forensics relies on analysis of short tandem repeats, but the Atlantic writes that newer tools and technologies are also being adapted to aid law enforcement investigations.

For instance, it notes that a break in a 25-year-old murder investigation came recently when investigators turned to DNA phenotyping by the Virginia-based Parabon NanoLabs that used a DNA sample left at the crime scene to put together a picture of what the suspect might look like.

Next-generation sequencing is also beginning to enter the field, the Atlantic says. It notes that the Illumina spin-out Verogen is now offering a forensics kit that works on Illumina sequencers to provide not only STR data, but also analyzes ancestry and traits like hair and eye color. But as Verogen's Cydne Holt tells the Atlantic, forensics scientists are a conservative lot. DNA sequencers are still undergoing validation for use in crime labs, it notes.

Despite that, the Atlantic notes that there's little oversight of how law enforcement uses DNA forensics. The New York Times and ProPublica recently critiqued of some of the algorithms used in STR analysis by the New York medical examiner.

"There will be new ways of using DNA to solve crimes, but there may be new ways of misusing DNA, too," the Atlantic cautions.

The Scan

Support for Moderna Booster

An FDA advisory committee supports authorizing a booster for Moderna's SARS-CoV-2 vaccine, CNN reports.

Testing at UK Lab Suspended

SARS-CoV-2 testing at a UK lab has been suspended following a number of false negative results.

J&J CSO to Step Down

The Wall Street Journal reports that Paul Stoffels will be stepping down as chief scientific officer at Johnson & Johnson by the end of the year.

Science Papers Present Proteo-Genomic Map of Human Health, Brain Tumor Target, Tool to Infer CNVs

In Science this week: gene-protein-disease map, epigenomic and transcriptomic approach highlights potential therapeutic target for gliomas, and more