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To Stop Bird Flu

Researchers in the UK have edited chicken cells in the lab to be resistant to bird flu, Reuters reports.

It notes that bird flu can pass quickly been wild birds and poultry, and sometimes infect humans, which many health officials see a major concern as it could lead to a pandemic.

By using the CRISPR gene-editing tool to disrupt the production of the ANP32 protein, researchers from Imperial College London and the University of Edinburgh prevented the virus from spreading in chicken cells in the lab. The bird flu virus relies on the ANP32 protein to infect its host, Reuters notes.

The researchers tell Reuters that they first need to explore what any other effects of making this gene edit might be before developing chickens with the alteration. Still, the Roslin Institute's Mike McGrew, who co-led the work, says in a statement that "[t]his is an important advance that suggests we may be able to use gene-editing techniques to produce chickens that are resistant to bird flu."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.