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Single-Cell Transcriptome Study Suggests Dual Pathways Behind in Immune Neoplasm

For a paper in Science Immunology, an international team led by investigators at the Karolinska Institute describes two lineages of Langerhans cell histiocytosis (LCH) lesions — an immune neoplasm marked by altered MAP kinase signaling pathway activity and mononuclear phagocyte differentiation problems. Using single-cell RNA sequencing, high-dimensional microscopy, lineage tracing, and other analyses, the researchers compared LCH cells to one another and to non-neoplastic mononuclear phagocyte cells in the microenvironment, detecting distinct dendritic cell (DC) clusters resembling so-called DC2 or DC3/monocyte-like cells and LCH-driving interactions between them that were facilitated by Notch-dependent signaling. "Our data support the premise of Notch-dependent cross-talk between DC2 and DC3/monocyte lineages and show that cooperativity between these lineages has the capacity to promote the pathognomonic LCH program," the authors suggest, calling it a "convergent dual origin model of LCH."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find structural network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.