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Single-Cell Atlas of Drosophila Embryogenesis

An atlas of Drosophila embryonic development at single-cell resolution is published in Science this week, representing a new resource for its study. To build the atlas, a team led by scientists from the University of Washington used various sequencing techniques to profile chromatin accessibility at almost 1 million nuclei and gene expression in half a million nuclei from 11 overlapping windows spanning the entirety of Drosophila embryogenesis. Leveraging developmental asynchronicity within embryo collections, they further used deep neural network-based predictive modeling to precisely predict the developmental age of each nucleus, resulting in continuous, multimodal views of molecular and cellular transitions in absolute time. "With these data, the dynamics of enhancer usage and gene expression can be explored within and across lineages at the scale of minutes, including for precise transitions like zygotic genome activation," the study's authors write. "Although larval stages remain insufficiently profiled, we hope that these data and methods, together with the recently released large-scale adult atlas, bring us closer to the community-wide goal of a multi-modal Drosophila atlas spanning a continuum from zygote to adulthood."

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.