Skip to main content
Premium Trial:

Request an Annual Quote

Signatures of Age

Researchers have uncovered biomarker signatures that may indicate a person's risk of age-related diseases, Live Science reports.

To develop their aging signatures, researchers led by the Boston University School of Medicine's Thomas Perls analyzed 40 serum biomarkers in more than 4,700 participants in the Long Life Family Study. As they report in Aging Cell, 19 of these markers — which included IL-6, IGF1, and DHEA — changed with age and clustered into 26 signatures. They then correlated these signatures with cancer, cardiovascular disease, type 2 diabetes, and mortality risk.

From this, they found that 'Signature 2' was associated with lower mortality, morbidity, and better physical function, as compared to the more common 'Signature 1', which about half the people in the study had. They confirmed these two signatures and a further eight in a Framingham Heart Study dataset.

"We can now detect and measure thousands of biomarkers from a small amount of blood, with the idea of eventually being able to predict who is at risk of a wide range of diseases, long before any clinical signs become apparent," Perls says in a statement.

The Scan

Hormone-Based Gene Therapy to Sterilize Domestic Cat

A new paper in Nature Communication suggests that gene therapy could be a safer alternative to spaying domestic cats.

Active Lifestyle Linked to Type 2 Diabetes Prevention in People at High Genetic Risk

A study in the British Journal of Sports Medicine shows that an active lifestyle goes a long way in type 2 diabetes prevention.

Beneficial, Harmful Effects of Introgression Between Wild and Domesticated European Grapes

A paper in PNAS shows that European wild grapevines were an important resource for improving the flavor of cultivated wine grapes.

Genetic Ancestry of South America's Indigenous Mapuche Traced

Researchers in Current Biology analyzed genome-wide data from more than five dozen Mapuche individuals to better understand their genetic history.