Skip to main content
Premium Trial:

Request an Annual Quote

Sequencing-Based Approach Shows Promise for Sepsis Diagnosis

A new approach to sepsis diagnosis that combines host transcriptional profiling and broad-range metagenomic pathogen detection is presented in Nature Microbiology. Early diagnosis and the identification of causative pathogens are key to successful sepsis treatment yet doing so remains difficult due to the limitations of current culture-based microbiologic diagnostics. Adding additional complexity is the need to differentiate sepsis effectively from non-infectious systemic illnesses, which can have similar presentations clinically. To overcome these challenges, a group led by scientists from the University of California, San Francisco, developed a diagnostic method that combines integrated host and pathogen metagenomic RNA and DNA sequencing of whole blood and plasma with machine learning. In a prospective cohort of critically ill adults who had been admitted to the hospital, the researchers showed that the approach identified 99 percent of microbiologically confirmed sepsis cases, and predicted sepsis in 74 percent of suspected and 89 percent of indeterminate sepsis cases. "We suggest that integrating host transcriptional profiling and broad-range metagenomic pathogen detection from nucleic acid is a promising tool for sepsis diagnosis," the authors write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.