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Sequencing Analysis Uncovers CLL Patient Groups With Varying Treatment Responses

Whole-genome sequencing may be able to gauge which chronic lymphocytic leukemia patients are more likely to have particular clinical outcomes, a study in Nature Genetics reports. Researchers from the University of Oxford and elsewhere sequenced the whole genomes of tumor and matched normal tissue samples from 485 CLL patients from the 100,000 Genomes Project. RNA-seq and ATAC-seq data was also available for a subset of patients. Through this, the researchers identified recurrent mutations, including known and putative driver genes. They additionally uncovered a number of translocations that affect regulatory elements and could point to potential drug targets. Further, a number of the features the researchers uncovered could together group patients into five clusters that associated with treatment response. "Robust testing on independent cohorts of patients undergoing targeted therapy will be required to further establish the clinical utility of this WGS-based classifier," they note.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.