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Scientists Develop Platform for Detecting Protein-Metabolite Interactions

A new mass spectrometry-based technology for studying protein-metabolite interactions (PMI) is presented in Science this week. The interactions between proteins and small-molecule metabolites influence a wide range of cellular processes. However, the identification of PMIs has been sporadic and strategies to discover such interactions are limited. Further, PMIs are frequently low affinity, further complicating their identification. A University of Utah School of Medicine-led team has now developed a platform called MIDAS, short for mass spectrometry integrated with equilibrium dialysis for the discovery of allostery systematically. They use MIDAS to analyze 33 enzymes from human carbohydrate metabolism, uncovering 830 protein-metabolite interactions, including known regulators, substrates, and products as well as previously unreported interactions. "MIDAS serves as a conduit to identify, understand, and exploit previously unknown modes of metabolic regulation across the protein-metabolite interactome," the researchers write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

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Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.