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Science Papers Present Approach to Predict 3D RNA Structures, Endometrial Therapeutic Target

A new computational method for predicting three-dimensional RNA structures is reported in Science this week. RNA molecules fold into well-defined 3D structures that are critical to their function and are of interest in drug discovery. Yet few RNA structures are known and predicting them remains challenging. To address this, a group of Stanford University researchers developed a machine learning approach, trained on 18 known RNA structures, that enables identification of accurate structural models without assumptions about their defining characteristics. Called the Atomic Rotationally Equivariant Scorer, or ARES, this neural network outperforms previous methods and consistently produces the best results in community-wide blind RNA structure prediction challenges, its developers write. "Because [ARES] uses only atomic coordinates as inputs and incorporates no RNA-specific information, this approach is applicable to diverse problems in structural biology, chemistry, materials science, and beyond," they add.

By comparing the genetics of humans and rhesus macaques, a group led by scientists from the University of Oxford has identified a nonhormonal therapeutic target for endometriosis. Endometriosis is a chronic condition, characterized by the growth of endometrial-like tissues outside of the uterus, with significant heritability and treatment options limited to hormonal therapy or surgery. Aiming to better understand the disorder, the investigators sequenced DNA from 32 human families with endometriosis and compared the findings to a genetic analysis in a large, multigenerational pedigree of rhesus macaques that spontaneously develop the condition. As reported in Science Translational Medicine, they identify NPSR1, the gene encoding neuropeptide S receptor 1, as associated with disease. In follow-on experiments, a NPSR1 inhibitor led to reduction of inflammatory cell infiltrate and pain in mouse models of peritoneal inflammation and endometriosis. While additional study is needed, the findings point to a genetically validated, nonhormonal target for the treatment of endometriosis with likely increased relevance to later-stage disease, the study authors write.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.