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A method that combines CRISPR interference with barcoded expression reporter sequencing to generate phenotypic profiles for tracking genetic interactions is reported in Science this week. Using the approach, called CiBER-seq, its developers at the University of California, Berkeley linked a library of CRISPR guide RNAs to their individual phenotypic consequences using pooled sequencing in yeast, fully recapitulating the integrated stress response pathway in the model organism.

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In a letter, about two dozen researchers criticize the World Health Organization investigation into the origins of SARS-CoV-2 and call for a new inquiry, the Wall Street Journal reports.

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