Skip to main content
Premium Trial:

Request an Annual Quote

Science Paper Examines Influence of Chromatin Modifications on Obsessive-Compulsive Disorder

By sequencing the genomes of people with obsessive-compulsive disorder and members of their families, a team of Shanghai Jiao Tong University scientists has uncovered mutations that implicate chromatin modifications in the condition. Building off of previous exome-sequencing studies for OCD, the researchers performed whole-genome sequencing on 53 parent-offspring families with offspring affected with OCD to investigate all rare de novo variants and insertions/deletions. They found strong evidence for a high occurrence of mutation at promoter-interacting loops and observed that de novo mutations preferentially occurred on intolerant genes and affected genes regulating chromatin modification. As reported in Science Advances, the investigators identify three high-confidence chromatin modifiers as OCD candidate risk genes.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.