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A combination of CRISPR gene editing and single-cell RNA sequencing is used to create a framework for studying genetic interactions (GIs) and their impact on cellular phenotypes in a study appearing in Science this week. The approach is based on a high-content phenotyping approach called single-cell RNA-seq pooled CRISPR screens, or Perturb-seq. The study's authors used Perturb-seq to manipulate a large number of gene pairs and then measure the resulting changes in cell state.

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The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.