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A combination of CRISPR gene editing and single-cell RNA sequencing is used to create a framework for studying genetic interactions (GIs) and their impact on cellular phenotypes in a study appearing in Science this week. The approach is based on a high-content phenotyping approach called single-cell RNA-seq pooled CRISPR screens, or Perturb-seq. The study's authors used Perturb-seq to manipulate a large number of gene pairs and then measure the resulting changes in cell state.

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Following its departure from the European Union, the UK is to implement a fast-track visa program aimed at attracting scientific talent to Britain, according to BBC News.

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In PLOS this week: common variant associated with BMI in Arctic populations, analysis of microRNA markers associated with being born small for gestational age, and more.