Skip to main content
Premium Trial:

Request an Annual Quote

Retrospective Study Weighs Germline Genetic Contributions to Oncology Trials

For a paper appearing in JAMA Network Open, investigators at the National Cancer Institute and the University of Maryland look back at the use of germline genetic clues in hundreds of oncology trials performed in the US, Canada, Europe, and elsewhere between the end of 1990 and spring of 2022. Drawing on data for almost 84,300 oncology trials in the Informa Trialtrove database, the team identified 887 trials with germline genetic data, including more than 450 trials with BRCA1 or BRC2 biomarker profiling and 367 trials with genetic testing focused on mechanisms related to PARP inhibitor treatment. "Consistent with our hypothesis, most trials currently using germline data prioritize BRCA1/2 and explore additional indications for PARP inhibitors (such as earlier-stage disease) in cancer types where PARP inhibitors already work," the authors report, adding that "[t]o expand the potential benefits of germline data in oncology across more patients, trials must expand beyond the well-trodden BRCA-PARP space."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.