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Retrospective Analysis Suggests Molecular Profiling Often Not Beneficial in Low-Grade Endometrial Cancer

In JAMA Network Open, researchers from Radboud University Medical Center and elsewhere share results suggesting routine molecular profiling beyond Lynch syndrome screening  may not improve outcomes for individuals with low-grade endometrial cancer — a condition that appeared to have favorable prognoses across its known molecular subtypes. Using next-generation sequence- and immunohistochemistry-based profiles, the team retrospectively classified almost 400 endometrial cases diagnosed in Europe from the mid-1990s through 2018 into four molecular subgroups: POLE-altered, microsatellite instable, TP53-altered, or no specific molecular profile. While five-year survival tended to be lower in patients with high-grade, TP53-altered, stage III or IV endometrial cancer, the authors found, low-grade endometrial cancer cases had favorable five-year survival patterns across the molecular subtypes considered. "The findings of this cohort study suggest that routine molecular profiling would not be beneficial in patients with low-grade [endometrial cancer] due to their excellent prognosis independent of molecular subgroup," they write. "Our data demonstrate the importance of primary diagnostic tumor grading and do not support routine molecular profiling in low-grade [endometrial cancer] as a cost-effective approach."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.