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Researchers Link Telomere Length With Alzheimer's Disease

A new study appearing in PLOS One this week has linked telomere shortening in certain immune cells to signs of Alzheimer's disease in the brain. Telomeres, the protective caps at the end of chromosomes, progressively shorten with each cell division. Their attrition is an established marker of biological aging and has been associated with susceptibility to age-related disease, but the mechanisms underlying that association is unclear. A team led by scientists from the University of Oxford has now compared leukocyte telomere length (LTL) with brain MRIs and electronic medical record data for around 31,000 UK Biobank participants. They found that longer LTL is associated overall with a reduced incidence of dementia, as well as a number of MRI phenotypes including larger volumes of grey matter and larger hippocampi. "Associations between LTL and brain structure provide a mechanism explaining the protective association of longer LTL on dementia incidence we observed," the study's authors conclude. "Accelerated cellular aging may represent a biological pathway to neurodegenerative disease."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.