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Qualitative Study Explores Perceptions of NGS-Based Tuberculosis Diagnoses

Investigators in Madagascar, Canada, Spain, and the US present findings from a qualitative analysis of Mycobacterium tuberculosis diagnostics centered on next-generation sequencing (NGS) in low- and high-income country settings. As they report in BMJ Open, the researchers turned to semi-structured interviews to assess perceptions of NGS-based tuberculosis (TB) diagnoses in nine stakeholders apiece from Madagascar and Canada, including six individuals working in clinical practice, six individuals tasked with disease surveillance and six individuals with laboratory or diagnostic expertise. Together, the team explained, the in-depth interviews revealed a handful of common themes, ranging from ethical, practical, or operational concerns to variable levels of understanding, experience, or comfort with available evidence levels. "There persists [an] important lack of familiarity with TB next-generation sequencing (TB NGS) applications among stakeholders in Canada and Madagascar," the authors write, noting that "[t]his translates into skepticism on the evidence underlying its use and its true potential value added within global public health systems."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.