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Prostate Cancer Predisposition Profiled in Chinese Patients

In PLOS Genetics, researchers from the Chinese University of Hong Kong and Fudan University characterize germline prostate cancer contributors in Han Chinese individuals diagnosed with the disease. With exome sequencing data, the team tracked down three dozen deleterious germline variants in 29 of the 100 patients profiled, affecting 25 genes falling in DNA damage repair (DDR), DNA methylation, and other pathways. When they attempted to confirm those findings in another 167 prostate cancer patients from Shanghai, they narrowed in on seven genes containing risky germline variants in both cohorts, while comparisons with germline sequences from cancer-free individuals from East Asia pointed to a dozen genes beyond of DDR mechanisms implicated in prostate cancer risk in the past. "Taken together," they write, "this study reveals a comprehensive germline mutation landscape in Chinese prostate cancer patients and discovers 12 novel non-DDR predisposition genes to lay the groundwork for the optimization of genetic screening."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.