Promise and Limits

Patient-derived xenograft mice are supposed to recapitulate patients' tumors so researchers can better model tumors or even so clinicians use them to choose a treatment approach. But as Nature News reports, these models have some limitations.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.