Skip to main content
Premium Trial:

Request an Annual Quote

Potential Protein ASD Markers

Proteins present in the saliva may be able to serve as biomarkers for autism, according to Clarkson University researchers.

As it reports in Autism Research, the team led by Clarkson's Alisa Woods used a nanoliquid chromatography-tandem mass spectrometry approach to analyze the salivary proteome of six individuals with autism spectrum disorders and compare it to the salivary proteome of neurotypical controls. In this pilot effort, they found that nine salivary proteins differed between the two groups, including lactotransferrin, prolactin-inducible protein, statherin, histatin 1, and more.

"We have identified potential biomarkers for autism diagnosis that are implicated in both heightened immune responses and gastrointestinal distress," Woods tells Medscape Medical News. "This is consistent with current ideas about autism cause and comorbidities."

The researchers note that the study was small and remains to be tested in a larger group as well as in ASD subtypes.

Matthew Siegel from the Maine Medical Center Research Institute, who was not involved in the study, tells Medscape Medical News that "examining saliva is attractive due to its accessibility, but will need to be tested in much larger samples to see if there are useful results."

The Scan

And a Fourth?

A fourth dose of the Pfizer-BioNTech SARS-CoV-2 vaccine in an Israeli study increased antibody levels but did not prevent Omicron variant infections, according to the Financial Times.

For Better Science Software

A virtual institute funded by former Google CEO Eric Schmidt's philanthropy aims to lure software engineers to academia, Science reports.

Recommendation Explanations

The New York Times writes that the US Centers for Disease Control and Prevention is straining to both make and explain decisions based on limited information.

Genome Research Papers on De Novo Mutation Rates, Polyploid Genotyping, Oncogene Epigenomic Translocation

In Genome Research this week: de novo mutations rates in hemoglobin subunits, analysis of variant calling methods for polyploid plants, and more.