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Researchers in China and the US describe recurrent alterations that inactive the mTORC1 signaling pathway gene DEPDC5 in gastrointestinal stromal tumors (GISTs), consistent with a potential tumor suppressor role for the gene. The team did exome sequencing on matched tumor and normal samples from 40 individuals with GIST, uncovering previously identified activating mutations in receptor tyrosine kinase genes such as KIT, along with the recurrent changes inactivating DEPDC5.

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