Skip to main content
Premium Trial:

Request an Annual Quote

From a Pig

Researchers have transplanted a genetically modified pig kidney into a human without triggering the patient's immune system, Reuters reports. It adds that this work could be a step toward addressing the shortage of organs available for transplant.

As Reuters notes, pig organs typically generate an immune response in people, but in this case, the researchers used an organ from a pig that was genetically altered to lack the glycan that sparks rejections. This GalSafe pig, developed by Revivicor, part of United Therapeutics, was approved by the US Food and Drug Administration in December 2020, it adds.

Researchers at New York University transplanted the GalSafe organ into a brain-dead patient with the family's consent, Reuters says. The researchers tell it that the kidney made the expected amount of urine, the patient's creatine levels returned to normal, and there were no signs of rejection.

"It had absolutely normal function," Robert Montgomery, who led the NYU team, tells the Associated Press. "It didn't have this immediate rejection that we have worried about."

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.