Skip to main content
Premium Trial:

Request an Annual Quote

Participants' Perspectives on Recall-by-Genotype Studies Gauged

A study investigating the social and ethical implications of recall-by-genotype (RbG) studies, which recruit participants previously involved in genetic research based on their genotypes, is presented in the European Journal of Human Genetics this week, offering insights that may help in the creation of participant-centered RbG policies. RbGs are becoming increasingly popular due to the growing availability of genotyping data from new sequencing technologies but face legal and ethical hurdles since they risk disclosing potentially unwanted or distressing genetic information to participants. Aiming to improve RbG study practices and policies, a team led by scientists from Italy's Eurac Research queried around 50 people taking part in an RbG study on the penetrance of Parkinson's disease variants, seeking feedback on their experiences. In the study, the disease under investigation was disclosed but the individual variant carrier status was not. They find that while the nondisclosure of carrier status in an RbG study was acceptable, the disclosure of a disease under investigation was important to participants. Still, participant preferences for the disclosure of such information varied according to how the knowledge of individual carrier status was perceived to impact participants lives. "A suitable communication strategy and granular options addressing preferences for invitation in the original informed consent are critical for an ethically informed RbG policy," the authors say.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.