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Parallel Sequencing Proves Cost-Effective in Advanced Non-Small Cell Lung Cancer Analysis

For a paper in JCO Precision Oncology, investigators in the Netherlands compare sequential, single-gene genetic testing approaches to next-generation sequencing approaches, both of which are used to search for informative genetic alterations, in advanced non-small cell lung cancer, focusing on the cost effectiveness of each approach. Using a combination of simulated and real world data, including insights for patients with stage IV non-squamous NSCLC from the Dutch Pathology Registry, the VU Amsterdam-led team considered diagnostic outcomes, quality-adjusted life year (QALY) gains, and cost-effectiveness for each approach, demonstrating that the parallel sequencing strategy edges out sequential gene testing on both the diagnostic and cost-effectiveness fronts. "NGS-based parallel testing is diagnostically superior over single gene-based sequential testing," the authors write, "as it is cheaper and more effective than sequential testing.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.