The Pair of Them

Matched tumor-normal pairs are necessary to reliably identify and interpret mutations found in patients' tumors to guide treatment, according to researchers from Johns Hopkins University School of Medicine and Personal Genome Diagnostics.

However, as Julia Karow writes at GenomeWeb, many diagnostic labs only sequence tumor tissue and not matched normal tissue, often for reasons of cost.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.