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Oxford Team Reports Single-Cell Alternative Splicing Analysis Tool

An integrated alternative splicing analysis platform geared for single-cell RNA sequencing data generated from the plate- and droplet-based methods is presented in Nucleic Acids Research. While alternative splicing represents an important layer of transcriptional complexity underlying gene expression, the ability to study it at the single-cell level is hampered by a lack of computational tools. To help fill in this gap, University of Oxford scientists developed MARVEL, an R package for integrative single-cell alternative splicing and gene expression analysis. They benchmark MARVEL against existing tools and show its utility by analyzing publicly available datasets generated from the plate- and droplet-based library preparation methods derived from induced pluripotent stem cells differentiated into endoderm and cardiomyocytes, respectively. "We anticipate MARVEL to be prospectively applied to single-cell datasets generated from various settings … to reveal novel biological insights," the developers write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.