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New Tool for Assessing Cost of ctDNA Testing

A framework for calculating the cost of circulating tumor DNA testing across different workflows is presented in the Journal of Molecular Diagnostics this week, providing a tool that can help labs and hospitals make informed investment decisions. As ctDNA testing becomes increasingly used in cancer care, estimating its total cost — a requirement for reimbursement and implementation — remains challenging due to variations in workflows. To help overcome this problem, researchers from the Netherlands Cancer Institute developed a framework that provides a consistent total cost calculation for ctDNA testing across different diagnostic workflows and platforms — including aspects such as personnel, materials, overhead, and failures — while taking test volume into account. The framework's developers also provide an open-access tool to allow for laboratory-specific calculations to explore the total costs of ctDNA testing-specific workflow parameters. The framework, they write, "can support investment decisions in clinical practice, as well as the calculation of the costs of ctDNA testing for future cost-effectiveness studies."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find structural network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.