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New Target for a Childhood Cancer

Using sequencing and other technologies, a team led by scientists from the St. Jude Children's Research Hospital have identified a new potential treatment target for alveolar rhabdomyosarcoma, an aggressive childhood soft tissue sarcoma. In a study appearing in this week's Science Translational Medicine, the researchers show that epigenetic histone alterations by a specific lysine demethylase, KDM4B, are required for the growth of a type of alveolar rhabdomyosarcoma characterized by the presence of the fusion protein Paired Box 3-Forkhead Box O1. Inhibition of KDM4 family members inhibited enhancer remodeling and, when combined with chemotherapy, led to reductions in tumor size in preclinical xenograft models. The findings, the authors write, "indicate that selectively inhibiting KDM4B by small molecules has translational potential in the context of a disease that is driven by a currently undruggable fusion oncoprotein.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find structural network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.