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An epigenomic analysis of neurons from Parkinson's disease patients reveals that the loss of TET2, a master regulator of cytosine modification status, can help protect the brain from the effects of the disease. In the study, which appears in Nature Neuroscience, Van Andel Institute scientists performed a genome-wide analysis of DNA methylation and hydroxymethylation at enhancers in neurons from Parkinson's disease patients and controls.

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