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Nature Papers Reveal SARS-CoV-2 Substrains

A genomic analysis of more than 45,000 complete SARS-CoV-2 genome sequences was published in this week's Communications Biology, revealing the existence of multiple substrains of the virus in the US, some of which have the potential to become more infectious. In the study, researchers from Michigan State University use SNP calling and other techniques to analyze the SARS-CoV-2 genomes and uncover evidence of four substrains and 11 prevalent missense mutations in the US. Notably, one of mutations is associated with a greater immune response in infected women versus infected men, and two others are likely to strengthen the folding stability of the SARS-CoV-2 spike and ORF8 proteins, which are used by the virus to infect and adapt to its host. Based on the substrains' different mutation profiles, two of them appear to have the potential to become more infectious, the study's authors write.

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.