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A new strategy for studying chromatin architecture that overcomes key limitations of current crosslinking-based chromosome conformation capture techniques is reported in Nature Biotechnology this week. Most methods used to investigate chromatin organization depend on extensive in situ crosslinking of protein with genomic DNA, which allows probing of the proximity between genomic loci mediated through the interacting proteins bound at each locus.

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In Nature this week: sister-chromatid-sensitive chromosome conformation capture approach, and more.