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A Wellcome Sanger Institute team has developed a new method to cluster cells by genotype using the genetic variants detected within the single-cell RNA sequencing reads. As reported in Nature Methods this week, the technique — called souporcell — uses sparse mixture model clustering with explicit ambient RNA modeling. In benchmarking experiments, souporcell outperforms existing methods, its developers write, and is robust across a range of parameters.

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The US Food and Drug Administration is to announce stricter standards for emergency authorizations of SARS-CoV-2 vaccines, reports the Washington Post.

The Associated Press reports Johnson & Johnson is starting a late-stage clinical trial of its candidate SARS-CoV-2 vaccine.

Bloomberg reports the budget of Operation Warp Speed is actually $18 billion, higher than the number typically cited.

In Genome Research this week: genomic analysis reveals role of super-spreaders in SARS-CoV-2, epigenetic drivers of cancer, and more.