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A new RNA editing approach that uses engineered RNAs to recruit endogenous ADAR enzymes is both precise and efficient, and may prove useful for both clinical and research applications, according to a new study in Nature Biotechnology. The technique, called leveraging endogenous ADAR for programmable editing of RNA, or LEAPER, uses short engineered ADAR-recruiting RNAs to recruit native ADAR1 or ADAR2 enzymes to change a specific adenosine to inosine.

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