Skip to main content
Premium Trial:

Request an Annual Quote

Multi-Tissue Proteome Data Identifies Possible Therapeutic Targets

By combining Mendelian randomization and colocalization analyses with multi-tissue protein quantitative trait loci, Washington University School of Medicine researchers have homed in on potentially druggable proteins. As they report in Genome Medicine, they identified 80 cerebrospinal fluid, 52 plasma, and nine brain proteins that they tied to 64, 49, and 15 disease-related phenotypes, respectively. By then folding in published data on the druggable genome, the researchers found that between about 67 and 86 percent of these proteins could be a potential therapeutic target. A handful could further be tied to drug compounds within DrugBank or ChEMBL. They in particular prioritized six CSF proteins, nine plasma proteins, and three brain proteins for further study. "We anticipate that in the future, much larger-scale studies using additional proteins from a more extensive set of tissues with more phenotypes will facilitate the drug repositioning process," they add.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find structural network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.