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Mouse Study Points to Potential for Messenger RNA-Based Vaccines Targeting HPV-Positive Tumors

In Science Translational Medicine, investigators at the University of Sao Paulo, the University of Pennsylvania, and other international centers present findings from mouse model studies of several messenger RNA (mRNA)-based vaccines developed to target human papillomavirus (HPV)-positive tumors. After administering individual shots of low-dose vaccines comprised of self-amplifying, unmodified, or nucleoside-modified, nonreplicating forms of the mRNA-lipid nanoparticles targeting the E7 oncoprotein of HPV-16, the team saw activation of CD8-positive T cells targeting E7, along with memory T cell activity that prevented or staunched tumor growth in mice with HPV infections or HPV-associated tumors. In addition, the authors say, the HPV-targeting mRNA vaccine approach appeared to compare favorably to previously reported DNA- and protein-based vaccine approaches. "Collectively, we demonstrated the immunogenicity and therapeutic efficacy of three different mRNA vaccines in extensive comparative experiments," the authors report. "Our data support further evaluation of these mRNA vaccines in clinical trials."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.