Skip to main content
Premium Trial:

Request an Annual Quote

Macular Degeneration Regulatory Risk Contributors Found

In PLOS Biology, researchers from Tel Aviv University and other centers in Israel report on findings from a tissue-specific transcription factor-based approach for untangling regulatory shifts behind adult-onset macular degeneration (AMD), an eye condition that affects the retinal pigmented epithelium (RPE). With RNA sequencing, chromatin immunoprecipitation sequencing, and other analyses of human embryonic stem cell-derived RPE cells, the team focused in on a regulatory module that includes the LHX2 and OTX2 transcription factors — a regulatory region that was subsequently linked to TRPM1 expression and to a known AMD-associated locus through expression quantitative trait locus, ATAC-seq, and reporter assay analyses. "Through functional and genomic analyses, we reveal that LHX2 functions upstream and together with OTX2 on shared genomic regions (cistrome) in regulation of target genes," the authors report, adding that "intersecting the map of the LHX2-OTX2 bound cistrome with published genomic data on AMD revealed a causal non-coding risk SNP that acts by altering TRPM1 expression in the RPE through the modulation of LHX2 binding to its promoter."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.