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Lung Function Linked to Locus Moderated by Smoking Exposure, Methylation in Urban Children

For a paper appearing in PLOS Genetics, researchers at the University of Chicago and other centers describe early lung function impairment-linked features found in children living in urban environments. Starting with a genome-wide association study that included more than 1,000 children from low-income, urban neighborhoods, the team narrowed in on a chromosome 14 locus encompassing the TDRD9 gene that tracked with a lung function measurement known as "percent predicted forced expiratory volume in one second" (FEV1). That association, in turn, appeared to be moderated by tobacco smoke exposure-related DNA methylation levels at the locus in airway cells in a series of subsequent Mendelian randomization and mediation analyses. Together, these and other findings point to "a potential mechanism through which genetic risk and environmental exposures can affect airway development," the authors say, "perhaps leading to interventions that can help reduce the burden of asthma in socioeconomically disadvantaged children."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.